Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection

Wen-Jun Feng; Yan-He Wu; Xiao-Yang Liu; Zheng-Ke Wang

doi:10.1007/s10118-024-3146-0

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Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection

RESEARCH ARTICLE | Updated：2024-08-06

- Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection
- Chinese Journal of Polymer Science Vol. 42, Issue 8, Pages: 1147-1155(2024)
- Affiliations：
  
  MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
- Author bio：
  
  wangzk@zju.edu.cn
- Funds：
- DOI：10.1007/s10118-024-3146-0
  CLC：
- Published：01 August 2024，
  
  Published Online：26 June 2024，
  
  Received：05 March 2024，
  
  Revised：21 April 2024，
  
  Accepted：24 April 2024
- Accepted：
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Feng, W. J.; Wu, Y. H.; Liu, X. Y.; Wang, Z. K. Shear-thinning catechol-modified chitosan hydrogel loaded with silver nanoparticles for endoscopic submucosal dissection. Chinese J. Polym. Sci. 2024, 42, 1147–1155

Wen-Jun Feng, Yan-He Wu, Xiao-Yang Liu, et al. Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection. [J]. Chinese Journal of Polymer Science 42(8):1147-1155(2024)
Feng, W. J.; Wu, Y. H.; Liu, X. Y.; Wang, Z. K. Shear-thinning catechol-modified chitosan hydrogel loaded with silver nanoparticles for endoscopic submucosal dissection. Chinese J. Polym. Sci. 2024, 42, 1147–1155 DOI： 10.1007/s10118-024-3146-0.

Wen-Jun Feng, Yan-He Wu, Xiao-Yang Liu, et al. Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection. [J]. Chinese Journal of Polymer Science 42(8):1147-1155(2024) DOI： 10.1007/s10118-024-3146-0.

摘要

A kind of injectable shear-thinning hydrogel for endoscopic submucosal dissection was developed

which has excellent shear-thinning and self-healing properties. And it can maintain more durable submucosal cushion height than normal saline. Integrated with good antibacterial activity

hemocompatibility and cytocompatibility

the hydrogel demonstrates a superiority in accelerating wound healing after operation.

Abstract

Shear-thinning hydrogels have emerged for endoscopic submucosal dissection

while wound intervention after surgery has rarely been mentioned. Herein

a catechol-modified chitosan hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound healing. Benefiting from the shear-thinning and self-healing characteristics

the as-prepared hydrogel showed easily endoscopic injectability. It also performed very well as submucosal cushion

which could remain above 70% after injection for 120 min in

ex vivo

porcine large intestine model. In fact

the cushion height of normal saline dramatically decreased to 46% of the initial height at 30 min. Ag nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100% antibacterial effect against

E. coli

and

S. aureus.

The hemolysis ratio of the hydrogel was calculated to be as low as 0.8%. Combined with good hemocompatibility and cytocompatibility

the as-prepared hyd

rogel displayed much higher

in vivo

wound closure and healing efficacy than normal saline. These results demonstrated the superiority of the shear-thinning chitosan hydrogel in facilitating clinical endoscopic submucosal dissection surgery.

关键词

Keywords

Shear-thinning hydrogelEndoscopic mucosal dissectionWound healingCatechol-modified chitosanSilver nanoparticles

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