Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Chi-Yun Ma; Xue-Wei Dong; Xue-Mei Lu; Bing Yuan; Kai Yang

doi:10.1007/s10118-024-3222-5

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Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

RESEARCH ARTICLE | Updated：2024-11-07

- Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode
- Chinese Journal of Polymer Science Vol. 42, Pages: 1-10(2024)
- Affiliations：
  
  a.Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China
  b.State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
  c.School of Optical and Electronic Information, Suzhou City University, Suzhou 215104, China
  d.School of Physical Science and Technology, Jiangsu Key Laboratory of Thin Films, Soochow University, Suzhou 215006, China
  e.Songshan Lake Materials Laboratory, Dongguan 523808, China
- Author bio：
  
  dongxuewei@suda.edu.cn (X.W.D.)
  yangkai@suda.edu.cn (K.Y.)
- Funds：
- DOI：10.1007/s10118-024-3222-5
  CLC：
- Published：2024-09，
  
  Published Online：07 November 2024，
  
  Received：18 July 2024，
  
  Revised：15 August 2024，
  
  Accepted：19 August 2024
- Accepted：
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Ma, C. Y.; Dong, X. W.; Lu, X. M.; Yuan B.; Yang, K. Nanoparticle induces membrane fusion in a state-wise and property-sensitive mode. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-024-3222-5

Chi-Yun Ma, Xue-Wei Dong, Xue-Mei Lu, et al. Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode. [J/OL]. Chinese Journal of Polymer Science, 2024,421-10.
Ma, C. Y.; Dong, X. W.; Lu, X. M.; Yuan B.; Yang, K. Nanoparticle induces membrane fusion in a state-wise and property-sensitive mode. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-024-3222-5 DOI：

Chi-Yun Ma, Xue-Wei Dong, Xue-Mei Lu, et al. Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode. [J/OL]. Chinese Journal of Polymer Science, 2024,421-10. DOI： 10.1007/s10118-024-3222-5.

摘要

Abstract

Membrane fusion is essential for many cellular physiological functions

which is modulated by highly precise molecular mechanism involving multiple energy barriers. Nanoparticles (NPs)

which exhibit immense potential in the field of biomedical applications

can act as fusogen proteins to initiate and regulate membrane fusion. However

the underlying mechanisms of NP-induced membrane fusion and the molecular details involved remain largely elusive. Here

using coarse-grained molecular dynamics simulations

we systematically investigate the NP-induced membrane fusion behaviors and the influences of NP properties (size

hydrophobicity and hydrophilicity). Our results show that the vesicle-bilayer fusion induced by a hydrophobic NP is an intricately state-wise process

involving the approach and local deformation of the vesicle and bilayer bridging by the NP

the flip-flop of lipids from proximal leaflets and the formation of a fusion stalk

as well as further lipid interactions between distal leaflets and complete fusion. Moreover

we find that NP properties have distinct effects on membrane fusion and thus the optimal NP conditions for facilitating membrane fusion are obtained. Our work provides a mechanistic understanding of NP-induced membrane fusion and offers useful insights for efficient and controlled regulation of membrane fusion.

关键词

Keywords

NanoparticleMembrane fusionMolecular dynamics simulationCoarse-grained model

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